Haldol Drops Overdosage

Symptoms: The manifestations are an exaggeration of the known pharmacological effects and adverse reactions. The most prominent symptoms are: severe extrapyramidal reactions, hypotension, sedation. An extrapyramidal reaction is manifest by muscular rigidity and a generalised or localised tremor. Hypertension rather than hypotension is also possible.
In extreme cases, the patient would appear comatose with respiratory depression and hypotension that could be severe enough to produce a shock-like state. The risk of ventricular arrhythmias, possibly associated with QT-prolongation, should be considered.
Treatment: There is no specific antidote. Treatment is largely supportive. Activated charcoal may be administered.
For comatose patients, a patent airway should be established by use of an oropharyngeal airway or endotracheal tube. Respiratory depression may necessitate artificial respiration.
ECG and vital signs should be monitored and monitoring should continue until the ECG is normal. Severe arrhythmias should be treated with appropriate anti-arrhythmic measures.
Hypotension and circulatory collapse may be counteracted by use of intravenous fluids, plasma, or concentrated albumin and vasopressor agents such as dopamine or noradrenaline. Adrenaline should not be used, since it might cause profound hypotension in the presence of Haldol.
In cases of severe extrapyramidal reactions, antiparkinson medication (e.g. benztropine mesylate 1 to 2 mg IM or IV) should be administered parenterally.